In primary polycythemia, abnormalities in the production of red blood cells cause a high red blood cell count. Alcohol’s indirect effects include nutritional deficiencies that impair the production and function of various blood cells. Many conditions — including infections, liver disease and some cancers — can cause an enlarged spleen, also known as splenomegaly (spleh-no-MEG-uh-lee).An enlarged spleen usually doesn't cause symptoms. Macrocytosis is the term for enlarged red blood cells. ; 2009. If low folate is found to be the cause of the macrocytic anemia, folate supplementation often follows. These studies measure the concentration of red cells in the blood, their size, variability, volume and other factors. A single copy of these materials may be reprinted for noncommercial personal use only. Of enlarged red blood cells are due to alcohol consumption will the condition be fixed by reducing or eliminating - Answered by a verified Doctor ... iron and folate are all normal. Therefore, low levels of either of these B vitamins can lead to large red blood cells. For some patients, once the underlying cause is dealt with, the enlarged spleen will go back to its normal size. I feel fine. Your blood test results This author has been verfied for credibility and expertise. Over a year ago, I lost over 30 pounds, lost all my muscle mass, get lightheaded easily and feel fatigued. A low red blood cell count is called anemia. With treatment of the underlying cause of your enlarged spleen, you can go on to live a normal, healthy life. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, Advertising and sponsorship opportunities, A side effect of certain medications, such as those used to treat cancer, seizures and autoimmune disorders, Increased red blood cell production by the bone marrow to correct anemia, for example, after blood loss, An underlying bone marrow cancer called myelodysplastic syndrome. Common causes of macrocytosis include: If you have macrocytosis, blood tests can help determine its cause. If a person is alcoholic, medically supervised alcohol cessation and treatment for any nutrient deficiencies is in order. Exuberant T suppressor cell activity suppressing erythropoiesis has been demonstrated in certain cases of pure red blood cell aplasia. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Oxygen entering the lungs adheres to this protein, allowing blood cells to transport oxygen throughout the body. If this is something you are concerned about, I would suggest seeing your primary care physician soon so that you can have repeat blood counts and coagulation tests. He is a pathologist and has experience in internal medicine and cancer research. I was also once on monthly B12 injections for a year. Red blood cells are the most abundant type of blood cell. American Family Physician. Macrocytosis is the enlargement of red blood cells with near-constant hemoglobin concentration, and is defined by a mean corpuscular volume (MCV) of greater than 100 femtolitres (the precise criterion varies between laboratories). Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Macrocytosis is a term used to describe red blood cells that are larger than normal. They carry oxygen through the body from the lungs to the tissues. The primary function of the red blood cell is to transport oxygen to all parts of the body. Hemoglobin is a protein in red blood cells. I was with my sister when she got back the results of some routine blood work, and the test showed she has enlarged red blood cells. Also known as megalocytosis or macrocythemia, this condition typically causes no signs or symptoms and is usually detected incidentally on routine blood tests. Clinic Health system locations > < br > < br > this organ is part of your spleen! Have roots meaning `` big cell '' ) party products and services advertised polyclonal B activation..., Florida and Minnesota and at mayo Clinic common causes of macrocytosis consists of finding treating... The cells transport oxygen to all parts of the macrocytic anemia can … enlarged red blood cells ) have numbers! Term used to describe red blood cells of polycythemia can be due to many factors hormone levels are the of. 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